Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.
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| Title: | Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips. |
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| Authors: | Li J; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Peng W; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Kwok M; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China., Ding H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Zhuo D; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Southern University of Science and Technology Yantian Hospital, Shenzhen, China., Gurung B; Novoheart, Boston, MA, USA., Lakhani IR; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Yu H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Poon EN; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. ellen.poon@cuhk.edu.hk., Li RA; Novoheart, Boston, MA, USA.; Medera Biopharm, Boston, MA, USA., Yao X; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. yao2068@cuhk.edu.hk.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08639-8 |
