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Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.

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Title: Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.
Authors: Li J; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Peng W; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Kwok M; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China., Ding H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Zhuo D; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Southern University of Science and Technology Yantian Hospital, Shenzhen, China., Gurung B; Novoheart, Boston, MA, USA., Lakhani IR; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Yu H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Poon EN; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. ellen.poon@cuhk.edu.hk., Li RA; Novoheart, Boston, MA, USA.; Medera Biopharm, Boston, MA, USA., Yao X; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. yao2068@cuhk.edu.hk.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 25; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Peng+W%22">Peng W</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Kwok+M%22">Kwok M</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ding+H%22">Ding H</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhuo+D%22">Zhuo D</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Southern University of Science and Technology Yantian Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Gurung+B%22">Gurung B</searchLink>; Novoheart, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lakhani+IR%22">Lakhani IR</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Poon+EN%22">Poon EN</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. ellen.poon@cuhk.edu.hk.<br /><searchLink fieldCode="AU" term="%22Li+RA%22">Li RA</searchLink>; Novoheart, Boston, MA, USA.; Medera Biopharm, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Hong Kong, China. yao2068@cuhk.edu.hk.; Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk.
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