Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells.
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| Title: | Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells. |
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| Authors: | Umezaki N; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Boku S; Cancer Treatment Center, Kansai Medical University Hospital, 2-3-1 Shinmachi, Hirakata City, 573-1191, Osaka, Japan. boku.sho@kmu.ac.jp., Matsuo Y; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Yamamoto T; Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Higasiosaka City, 577-8502, Osaka, Japan., Satake H; Department of Medical Oncology, Kochi Medical School, Kochi University, Nankoku City, 783-8505, Kochi, Japan., Watanabe M; Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan., Hirota K; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Sugie T; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Sekimoto M; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan. |
| Source: | Scientific reports [Sci Rep] 2026 Mar 24; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-026-42753-z |
