Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells.
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| Title: | Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells. |
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| Authors: | Umezaki N; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Boku S; Cancer Treatment Center, Kansai Medical University Hospital, 2-3-1 Shinmachi, Hirakata City, 573-1191, Osaka, Japan. boku.sho@kmu.ac.jp., Matsuo Y; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Yamamoto T; Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Higasiosaka City, 577-8502, Osaka, Japan., Satake H; Department of Medical Oncology, Kochi Medical School, Kochi University, Nankoku City, 783-8505, Kochi, Japan., Watanabe M; Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan., Hirota K; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Sugie T; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan., Sekimoto M; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan. |
| Source: | Scientific reports [Sci Rep] 2026 Mar 24; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41876618 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Umezaki+N%22">Umezaki N</searchLink>; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Boku+S%22">Boku S</searchLink>; Cancer Treatment Center, Kansai Medical University Hospital, 2-3-1 Shinmachi, Hirakata City, 573-1191, Osaka, Japan. boku.sho@kmu.ac.jp.<br /><searchLink fieldCode="AU" term="%22Matsuo+Y%22">Matsuo Y</searchLink>; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+T%22">Yamamoto T</searchLink>; Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Higasiosaka City, 577-8502, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Satake+H%22">Satake H</searchLink>; Department of Medical Oncology, Kochi Medical School, Kochi University, Nankoku City, 783-8505, Kochi, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+M%22">Watanabe M</searchLink>; Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.<br /><searchLink fieldCode="AU" term="%22Hirota+K%22">Hirota K</searchLink>; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sugie+T%22">Sugie T</searchLink>; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sekimoto+M%22">Sekimoto M</searchLink>; Department of Surgery, Kansai Medical University, Hirakata City, 573-1191, Osaka, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Mar 24; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Mar 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE; In Process |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41876618 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-026-42753-z Languages: – Code: eng Text: English Titles: – TitleFull: Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Umezaki N – PersonEntity: Name: NameFull: Boku S – PersonEntity: Name: NameFull: Matsuo Y – PersonEntity: Name: NameFull: Yamamoto T – PersonEntity: Name: NameFull: Satake H – PersonEntity: Name: NameFull: Watanabe M – PersonEntity: Name: NameFull: Hirota K – PersonEntity: Name: NameFull: Sugie T – PersonEntity: Name: NameFull: Sekimoto M IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 03 Text: 2026 Mar 24 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2045-2322 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Scientific reports Type: main |
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