The chronopharmacology of atogepant in migraine prevention: A real-world evaluation of influence of timing of administration on effectiveness and tolerability.

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Title: The chronopharmacology of atogepant in migraine prevention: A real-world evaluation of influence of timing of administration on effectiveness and tolerability.
Authors: Iannone LF; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy., Sebastianelli G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Latina, Italy., Santis F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Corrado M; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy., Marcosano M; Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Ornello R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Grazzi L; Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Montisano DA; Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Cesaris F; Department of Health Sciences, AOU Careggi, Florence, Italy., Munafò A; Department of Health Sciences, AOU Careggi, Florence, Italy., Vigani G; Department of Health Sciences, AOU Careggi, Florence, Italy., Avino G; Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy., Trimboli M; Department of Neuroscience, Azienda Ospedaliera-universitaria 'Renato Dulbecco', Catanzaro, Italy., Albanese M; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Russo A; Department of Neurology, Università della Campania 'Luigi Vanvitelli', Napoli, Italy., Volta GD; U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia, Italy., Romozzi M; Neurology Unit, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Calabresi P; Neurology Unit, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Castro FL; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy., Boccalini A; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy., Merlo P; UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy., Prudenzano MP; Clinica Neurologica 'L. Amaducci', Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Puglia, Italy., Valente MR; Dipartimento di Neuroscienze, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy., Rainero I; Dipartimento di Neuroscienze, Città della Salute e della Scienza di Torino, Torino, Italy., Giuliani G; Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy., Altieri M; Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy., Fofi L; Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Doretti A; U.O. Neurologia, IRCCS Istituto Auxologico Italiano, Milan, Italy., Vaghi G; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy., Pistoia F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Lanni C; Department of Neurology, AOU Alessandria, Piemonte, Italy., Ferrandi D; Department of Neurology, AOU Alessandria, Piemonte, Italy., Rufa A; Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy., Battistini S; Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy., Coppola G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Latina, Italy., Geppetti P; Department of Health Sciences, University of Florence, Florence, Italy., Sacco S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Guerzoni S; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy., Altamura C; Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Vernieri F; Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Corporate Authors: Italian Headache Registry (RICe) Study Group
Source: Cephalalgia : an international journal of headache [Cephalalgia] 2026 Mar; Vol. 46 (3), pp. 3331024261416490. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1468-2982
DOI:10.1177/03331024261416490