Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis.
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| Title: | Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis. |
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| Authors: | Wang N; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen W; Department of General Surgery, Hefei Affiliated Hospital of Anhui Medical University, Hefei, 230011, China., Shen S; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Qi J; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China., Wang S; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Radiation Therapy, Anhui Chest Hospital, Hefei, 230026, China., Wang R; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Li M; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen Z; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen J; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. chenjm10@126.com., Hong B; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. bhong@hmfl.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. bhong@hmfl.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. bhong@hmfl.ac.cn., Wang H; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. wanghz@hfcas.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. wanghz@hfcas.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. wanghz@hfcas.ac.cn. |
| Source: | Molecular biomedicine [Mol Biomed] 2026 Mar 25; Vol. 7 (1). Date of Electronic Publication: 2026 Mar 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2662-8651 |
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| DOI: | 10.1186/s43556-026-00431-6 |
