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Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis.

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Title: Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis.
Authors: Wang N; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen W; Department of General Surgery, Hefei Affiliated Hospital of Anhui Medical University, Hefei, 230011, China., Shen S; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Qi J; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China., Wang S; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Radiation Therapy, Anhui Chest Hospital, Hefei, 230026, China., Wang R; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Li M; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen Z; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Chen J; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. chenjm10@126.com., Hong B; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. bhong@hmfl.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. bhong@hmfl.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. bhong@hmfl.ac.cn., Wang H; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. wanghz@hfcas.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. wanghz@hfcas.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. wanghz@hfcas.ac.cn.
Source: Molecular biomedicine [Mol Biomed] 2026 Mar 25; Vol. 7 (1). Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis.
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  Data: <searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of General Surgery, Hefei Affiliated Hospital of Anhui Medical University, Hefei, 230011, China.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China.; Department of Radiation Therapy, Anhui Chest Hospital, Hefei, 230026, China.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. chenjm10@126.com.<br /><searchLink fieldCode="AU" term="%22Hong+B%22">Hong B</searchLink>; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. bhong@hmfl.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. bhong@hmfl.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. bhong@hmfl.ac.cn.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui, 230031, China. wanghz@hfcas.ac.cn.; Science Island Branch, Graduate School of the University of Science and Technology of China, Hefei, Anhui, 230026, China. wanghz@hfcas.ac.cn.; School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China. wanghz@hfcas.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 Mar 25; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 Mar 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s43556-026-00431-6
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        Text: English
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      – TitleFull: Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis.
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              Text: 2026 Mar 25
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