GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis.

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Title: GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis.
Authors: Chen Y; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Liao F; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wang J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Breast Cancer Center, Zhejiang Cancer Hospital, Hangzhou, China., Zhao J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Xu Y; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Chen Q; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Hong T; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Lv K; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Li Q; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Chen X; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Xiao C; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wang L; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Li G; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Ke C; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Cai J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Li J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Sheng S; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wang J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wu X; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Ruan Y; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Zhang F; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wu R; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Xu Y; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Zhu W; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Xu Y; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China., Wang J; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; (Research Center for Life Science and Human Health), Binjiang Institute of Zhejiang University, Hangzhou, China., Ni C; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China. Electronic address: cescni@zju.edu.cn., Hu X; Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; (Research Center for Life Science and Human Health), Binjiang Institute of Zhejiang University, Hangzhou, China. Electronic address: hxy0507@zju.edu.cn.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2026 Apr; Vol. 11 (4), pp. 101518. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-302X
DOI:10.1016/j.jacbts.2026.101518