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Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.

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Title: Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.
Authors: Laycock K; Queen Mary University of London, London, UK kate.laycock@nhs.net.; St Bartholomew's Hospital, London, England, UK., Kearney J; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.; Endocrinology ASO/EASO COM, King's College Hospital NHS Trust, London, UK., Lee YN; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Macfarlane J; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Goodchild E; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Ng E; St Bartholomew's Hospital, London, England, UK., Pineau Mitchell A; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Wu X; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Htut Z; Imperial College London, London, England, UK., Goodchild G; Gastroenterology, St Bartholomew's Hospital, London, England, UK., Lowe D; The Royal London Hospital, London, England, UK., Hilliard N; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Godfrey E; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Qazi N; Imperial College London, London, England, UK., Bastos J; The Royal London Hospital, London, England, UK., Chua A; St Bartholomew's Hospital, London, England, UK., Mahroof R; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Palma A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Khatun A; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Varsani C; St Bartholomew's Hospital, London, England, UK., Benu D; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Pereira SP; Institute for Liver and Digestive Health, University College London, London, UK., Krishnamurthy M; Nuclear Medicine, St Bartholomew's Hospital, London, England, UK., Cheow H; Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Chung TT; Endocrine, University College London, London, England, UK., Carroll P; Endocrine, Guy's and St Thomas' Hospitals NHS Trust, London, England, UK., O'Toole S; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, England, UK., Wernig F; Imperial College London, London, England, UK., Gurnell M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK., Brown M; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK., Drake WM; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.
Source: BMJ open [BMJ Open] 2026 Mar 26; Vol. 16 (3), pp. e111798. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.
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  Data: <searchLink fieldCode="AU" term="%22Laycock+K%22">Laycock K</searchLink>; Queen Mary University of London, London, UK kate.laycock@nhs.net.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Kearney+J%22">Kearney J</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.; Endocrinology ASO/EASO COM, King's College Hospital NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lee+YN%22">Lee YN</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Macfarlane+J%22">Macfarlane J</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Goodchild+E%22">Goodchild E</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Ng+E%22">Ng E</searchLink>; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Pineau+Mitchell+A%22">Pineau Mitchell A</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Htut+Z%22">Htut Z</searchLink>; Imperial College London, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Goodchild+G%22">Goodchild G</searchLink>; Gastroenterology, St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Lowe+D%22">Lowe D</searchLink>; The Royal London Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Hilliard+N%22">Hilliard N</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Godfrey+E%22">Godfrey E</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Qazi+N%22">Qazi N</searchLink>; Imperial College London, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Bastos+J%22">Bastos J</searchLink>; The Royal London Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Chua+A%22">Chua A</searchLink>; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Mahroof+R%22">Mahroof R</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Palma+A%22">Palma A</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Khatun+A%22">Khatun A</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Varsani+C%22">Varsani C</searchLink>; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Benu+D%22">Benu D</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Pereira+SP%22">Pereira SP</searchLink>; Institute for Liver and Digestive Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Krishnamurthy+M%22">Krishnamurthy M</searchLink>; Nuclear Medicine, St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Cheow+H%22">Cheow H</searchLink>; Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Chung+TT%22">Chung TT</searchLink>; Endocrine, University College London, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Carroll+P%22">Carroll P</searchLink>; Endocrine, Guy's and St Thomas' Hospitals NHS Trust, London, England, UK.<br /><searchLink fieldCode="AU" term="%22O'Toole+S%22">O'Toole S</searchLink>; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, England, UK.<br /><searchLink fieldCode="AU" term="%22Wernig+F%22">Wernig F</searchLink>; Imperial College London, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Gurnell+M%22">Gurnell M</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.<br /><searchLink fieldCode="AU" term="%22Brown+M%22">Brown M</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.<br /><searchLink fieldCode="AU" term="%22Drake+WM%22">Drake WM</searchLink>; Queen Mary University of London, London, UK.; St Bartholomew's Hospital, London, England, UK.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2026 Mar 26; Vol. 16 (3), pp. e111798. <i>Date of Electronic Publication: </i>2026 Mar 26.
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