Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes.
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| Title: | Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes. |
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| Authors: | Thomson RES; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Gumulya Y; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Bengochea AW; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Foley G; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Zaugg J; Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Aagaard A; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ross CM; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Beckett J; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Bodén M; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Jurva U; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hayes MA; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Andersson S; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gillam EMJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia. e.gillam@uq.edu.au. |
| Source: | The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 2938-2964. Date of Electronic Publication: 2026 Mar 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00699-y |
