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Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of acute myeloid leukemia.

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Title: Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of acute myeloid leukemia.
Authors: Li YR; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA., Shen X; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA., Chen Y; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA., Zhu Y; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA., Huang J; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA., Oliai C; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Yang L; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Department of Bioengineering, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Molecular Biology Institute, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Goodman-Luskin Microbiome Center, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.
Source: Leukemia [Leukemia] 2026 May; Vol. 40 (5), pp. 880-893. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Li+YR%22">Li YR</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.; Department of Bioengineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Oliai+C%22">Oliai C</searchLink>; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Department of Bioengineering, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Molecular Biology Institute, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.; Goodman-Luskin Microbiome Center, University of California, Los Angeles, CA, USA. liliyang@ucla.edu.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2026 May; Vol. 40 (5), pp. 880-893. <i>Date of Electronic Publication: </i>2026 Mar 26.
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              Text: 2026 May
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