STAT4 drives optimal expansion and transcriptional repression of type I interferon pathway in inflammatory ILC2.

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Title: STAT4 drives optimal expansion and transcriptional repression of type I interferon pathway in inflammatory ILC2.
Authors: Pietropaolo G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Laboratory Affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, 00161, Rome, Italy.; IRCCS Neuromed, 86077, Pozzilli, IS, Italy., Scarno G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Candelotti AM; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Garzillo G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Di Censo C; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Peruzzi G; Center for Life Nano- & Neuro-Science, Istituto Italiano Di Tecnologia, Rome, Italy., Fionda C; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Stabile H; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Sozio F; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., D'Aquino C; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Molfetta R; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Leone F; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy.; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy., Cinicola BL; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Gori A; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Ciancaglini C; Innate Lymphoid Cells Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Santopolo S; Innate Lymphoid Cells Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Quatrini L; Innate Lymphoid Cells Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Zicari AM; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Shih HY; Neuro-Immune Regulome Unit, National Eye Institute, NIH, Bethesda, MD, USA., Mikami Y; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan., Gismondi A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Bernardini G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Hsu KC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Santoni A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; IRCCS Neuromed, 86077, Pozzilli, IS, Italy., Sozzani S; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; IRCCS Neuromed, 86077, Pozzilli, IS, Italy., Laffranchi M; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy. mattia.laffranchi@uniroma1.it., Sciumè G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy. giuseppe.sciume@uniroma1.it.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 26; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1420-9071
DOI:10.1007/s00018-026-06157-6