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Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.

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Title: Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.
Authors: Bendik I; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. igor.bendik@dsm-firmenich.com., Beck M; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Manderna A; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Roos FF; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Wang J; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., McCarthy D; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Schweiggert C; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Besheer A; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Baisley J; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Misic Z; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Mussler B; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Kuttenkeuler A; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Piomelli D; Rhizotomos Consulting, Irvine, CA, USA., Péter S; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. szabolcs.peter@dsm-firmenich.com.
Source: CNS drugs [CNS Drugs] 2026 May; Vol. 40 (5), pp. 709-723. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Comparative Study
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1179-1934
DOI:10.1007/s40263-026-01280-1