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Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.

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Title: Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.
Authors: Bendik I; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. igor.bendik@dsm-firmenich.com., Beck M; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Manderna A; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Roos FF; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Wang J; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., McCarthy D; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Schweiggert C; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Besheer A; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland., Baisley J; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Misic Z; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Mussler B; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland., Kuttenkeuler A; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada., Piomelli D; Rhizotomos Consulting, Irvine, CA, USA., Péter S; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. szabolcs.peter@dsm-firmenich.com.
Source: CNS drugs [CNS Drugs] 2026 May; Vol. 40 (5), pp. 709-723. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Comparative Study
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
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  Data: Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru<superscript>®</superscript>, vs an Oil-Based Formulation, Epidyolex<superscript>®</superscript>, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.
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  Data: <searchLink fieldCode="AU" term="%22Bendik+I%22">Bendik I</searchLink>; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. igor.bendik@dsm-firmenich.com.<br /><searchLink fieldCode="AU" term="%22Beck+M%22">Beck M</searchLink>; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Manderna+A%22">Manderna A</searchLink>; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Roos+FF%22">Roos FF</searchLink>; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada.<br /><searchLink fieldCode="AU" term="%22McCarthy+D%22">McCarthy D</searchLink>; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schweiggert+C%22">Schweiggert C</searchLink>; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Besheer+A%22">Besheer A</searchLink>; Science & Research, dsm-firmenich, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Baisley+J%22">Baisley J</searchLink>; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Misic+Z%22">Misic Z</searchLink>; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mussler+B%22">Mussler B</searchLink>; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kuttenkeuler+A%22">Kuttenkeuler A</searchLink>; Nutrasource Pharmaceutical & Nutraceutical Services Inc., Guelph, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Piomelli+D%22">Piomelli D</searchLink>; Rhizotomos Consulting, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Péter+S%22">Péter S</searchLink>; Health Nutrition & Care, dsm-firmenich, Wurmisweg 576, Campus Building 245, 4303, Kaiseraugst, Switzerland. szabolcs.peter@dsm-firmenich.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9431220 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1934 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211727047%22">11727047 </searchLink><i>NLM ISO Abbreviation: </i>CNS Drugs <i>Subsets: </i>MEDLINE
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