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CPNE1: A novel therapeutic target for myopia progression - from genetic GWAS discovery to functional validation in vitro and vivo.

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Title: CPNE1: A novel therapeutic target for myopia progression - from genetic GWAS discovery to functional validation in vitro and vivo.
Authors: Jia L; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China., Wei P; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China.; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, People's Republic Of China., Wang Y; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China., Xia Z; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China., Gao S; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China., Wang Y; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China. wangyan7143@vip.sina.com.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China. wangyan7143@vip.sina.com.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China. wangyan7143@vip.sina.com.; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, People's Republic Of China. wangyan7143@vip.sina.com., Han G; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, 300020, PR China. dovehanguoge@hotmail.com.; Nankai University Affiliated Tianjin Eye Hospital, Nankai University Optometry and Vision Sicence Insitute, Tianjin, 300020, PR China. dovehanguoge@hotmail.com.; Nankai University Eye Institute, Nankai University, Tianjin, 300020, PR China. dovehanguoge@hotmail.com.; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, People's Republic Of China. dovehanguoge@hotmail.com.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 26; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08050-z