Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.

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Title: Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.
Authors: Thapa C; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Oh EK; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Sirkin D; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Lahey J; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., de León Guerrerro SD; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., McCarroll A; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Gowda P; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Zhang H; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Barishman A; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Peyton L; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Zhang S; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Pollak RM; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Hart RP; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA., Pato CN; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Kreimer A; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Mulle JG; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA., Sanders AR; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Pang Z; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Duan J; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 01. Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.02.27.708613