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Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.

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Title: Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.
Authors: Thapa C; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Oh EK; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Sirkin D; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Lahey J; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., de León Guerrerro SD; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., McCarroll A; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Gowda P; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Zhang H; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Barishman A; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Peyton L; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA., Zhang S; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Pollak RM; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Hart RP; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA., Pato CN; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Kreimer A; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Mulle JG; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA., Sanders AR; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Pang Z; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Duan J; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 01. Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.
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  Data: <searchLink fieldCode="AU" term="%22Thapa+C%22">Thapa C</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Oh+EK%22">Oh EK</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sirkin+D%22">Sirkin D</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lahey+J%22">Lahey J</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22de+León+Guerrerro+SD%22">de León Guerrerro SD</searchLink>; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22McCarroll+A%22">McCarroll A</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gowda+P%22">Gowda P</searchLink>; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Barishman+A%22">Barishman A</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Peyton+L%22">Peyton L</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pollak+RM%22">Pollak RM</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hart+RP%22">Hart RP</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Pato+CN%22">Pato CN</searchLink>; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kreimer+A%22">Kreimer A</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mulle+JG%22">Mulle JG</searchLink>; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+AR%22">Sanders AR</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pang+Z%22">Pang Z</searchLink>; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.; Center for NeuroMetabolism, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Center for Psychiatric Genetics, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
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        Value: 10.64898/2026.02.27.708613
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