Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid®): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.

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Title: Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid®): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.
Authors: Avadanei-Luca S; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Moraru DC; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Bulgaru-Iliescu AI; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Tatar R; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania., Nacea I; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania., Amarandei AH; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Constantinescu MC; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Pertea M; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.
Source: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2026 Mar 23; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Systematic Review; Review
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629322 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-3271 (Electronic) Linking ISSN: 20763271 NLM ISO Abbreviation: Med Sci (Basel) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2076-3271
DOI:10.3390/medsci14010157