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Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid®): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.

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Title: Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid®): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.
Authors: Avadanei-Luca S; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Moraru DC; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Bulgaru-Iliescu AI; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Tatar R; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania., Nacea I; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania., Amarandei AH; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Constantinescu MC; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania., Pertea M; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.
Source: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2026 Mar 23; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Systematic Review; Review
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629322 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-3271 (Electronic) Linking ISSN: 20763271 NLM ISO Abbreviation: Med Sci (Basel) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid<superscript>®</superscript>): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.
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  Data: <searchLink fieldCode="AU" term="%22Avadanei-Luca+S%22">Avadanei-Luca S</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Moraru+DC%22">Moraru DC</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Bulgaru-Iliescu+AI%22">Bulgaru-Iliescu AI</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Tatar+R%22">Tatar R</searchLink>; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Nacea+I%22">Nacea I</searchLink>; Grigore Alexandrescu Clinica Emergency Hospital for Children Bucharest, 010621 Bucharest, Romania.; Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Amarandei+AH%22">Amarandei AH</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Constantinescu+MC%22">Constantinescu MC</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Pertea+M%22">Pertea M</searchLink>; Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Plastic Surgery and Reconstructive Microsurgery, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.
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  Data: <searchLink fieldCode="JN" term="%22101629322%22">Medical sciences (Basel, Switzerland)</searchLink> [Med Sci (Basel)] 2026 Mar 23; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Mar 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101629322 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2076-3271 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220763271%22">20763271 </searchLink><i>NLM ISO Abbreviation: </i>Med Sci (Basel) <i>Subsets: </i>MEDLINE
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        Value: 10.3390/medsci14010157
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        Text: English
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              Text: 2026 Mar 23
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