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Progress and new challenges in image-based profiling.

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Title: Progress and new challenges in image-based profiling.
Authors: Serrano E; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Peters J; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, USA., Wagner J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom., Graham RE; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom., Chen Z; Calico Life Sciences, South San Francisco, CA, USA., Feng BY; Calico Life Sciences, South San Francisco, CA, USA., Miranda G; Department of Computational Science and Technology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden., Kalinin AA; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vulliard L; Systems Immunology and Single-Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Tomkinson J; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Mattson C; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Lippincott MJ; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Kang Z; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland., Sitani D; Department of Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Bunten D; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA., Seal S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Carragher NO; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marin Zapata PA; Bayer AG, Berlin, Germany., Caicedo JC; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, USA., Way GP; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. gregory.way@cuanschutz.edu.
Source: Molecular systems biology [Mol Syst Biol] 2026 May; Vol. 22 (5), pp. 624-658. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article; Review
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Serrano+E%22">Serrano E</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Peters+J%22">Peters J</searchLink>; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+J%22">Wagner J</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Graham+RE%22">Graham RE</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Calico Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+BY%22">Feng BY</searchLink>; Calico Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miranda+G%22">Miranda G</searchLink>; Department of Computational Science and Technology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kalinin+AA%22">Kalinin AA</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vulliard+L%22">Vulliard L</searchLink>; Systems Immunology and Single-Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Tomkinson+J%22">Tomkinson J</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Mattson+C%22">Mattson C</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lippincott+MJ%22">Lippincott MJ</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Kang+Z%22">Kang Z</searchLink>; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sitani+D%22">Sitani D</searchLink>; Department of Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bunten+D%22">Bunten D</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Seal+S%22">Seal S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carragher+NO%22">Carragher NO</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carpenter+AE%22">Carpenter AE</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marin+Zapata+PA%22">Marin Zapata PA</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Caicedo+JC%22">Caicedo JC</searchLink>; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Way+GP%22">Way GP</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA. gregory.way@cuanschutz.edu.
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