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CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease.

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Title: CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease.
Authors: Nagata H; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Nagayoshi Y; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Chujo T; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Kaneko H; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Nishiguchi K; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Kakizoe Y; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Ijima H; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Jinnouchi Hospital, Kumamoto, Japan., Sakakida K; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Masuda T; Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan.; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Ohtsuki S; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Wei FY; Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan., Takahashi Y; Department of Anatomy and Neurobiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Division of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan., Fukuda T; Department of Anatomy and Neurobiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Jinnouchi H; Jinnouchi Hospital, Kumamoto, Japan., Adachi Y; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Gastroenterological Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Yamamura R; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Matsushita K; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Adachi M; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Yokoi H; Department of Nephrology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Nakamura K; Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Nakazato H; Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Tomizawa K; Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. tomikt@kumamoto-u.ac.jp.; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan. tomikt@kumamoto-u.ac.jp.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 3206-3229. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-026-00759-3