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The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.

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Title: The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.
Authors: Choi RB; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Yoon SH; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Kotsalidis PE; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Houghton CH; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., George M; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Brooks DJ; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Zhao Y; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Bouxsein ML; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Wein MN; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States.; Harvard Stem Cell Institute, Cambridge, MA 02138, United States.
Source: JBMR plus [JBMR Plus] 2026 Mar 06; Vol. 10 (4), pp. ziag032. Date of Electronic Publication: 2026 Mar 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101707013 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4039 (Electronic) Linking ISSN: 24734039 NLM ISO Abbreviation: JBMR Plus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2473-4039
DOI:10.1093/jbmrpl/ziag032