Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism.

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Bibliographic Details
Title: Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism.
Authors: Rosenfield K; Division of Cardiology, Massachusetts General Hospital, Boston., Klok FA; Division of Thrombosis and Hemostasis, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Piazza G; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston., Sharp ASP; University College Dublin School of Medicine, Dublin.; Boston Scientific, Galway, Ireland., Ní Áinle F; University College Dublin School of Medicine, Dublin., Jaff MR; Boston Scientific, Marlborough, MA., Barco S; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.; Department of Vascular Medicine, University Hospital Zurich, Zurich, Switzerland., Goldhaber SZ; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston., Kucher N; Department of Vascular Medicine, University Hospital Zurich, Zurich, Switzerland., Lang IM; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna., Schmidtmann I; Department of Biostatistics and Bioinformatics, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Sterling KM; Boston Scientific, Marlborough, MA., Araszkiewicz A; Department of Cardiology, Poznan University of Medical Sciences, Poznań, Poland., Arora V; Augusta University, Augusta, GA., Cires-Drouet R; University of Texas Southwestern Medical Center, Dallas., Coghlan J; Royal Free Hospital, London., Hobohm L; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.; Department of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Ito WD; Department of Angiology and Cardiology, Heart and Vascular Center Klinikverbund Allgäu, Klinik Immenstadt, Immenstadt, Germany., Jacobson K; Division of Cardiovascular Medicine, University of Wisconsin Hospitals and Clinics, Madison., Kaiser C; University Hospital Basel, Basel, Switzerland., Kopec G; Department of Cardiac and Vascular Diseases, Pulmonary Circulation Center, Jagiellonian University Medical College, Krakow, Poland.; Department of Cardiac and Vascular Diseases, St. John Paul II Hospital, Krakow, Poland., Marx K; Department of Cardiology and Intensive Care Medicine, University Hospital Ostwestfalen-Lippe of Bielefeld University, Campus Klinikum Bielefeld, Bielefeld, Germany., McElwee S; University of Alabama at Birmingham, Birmingham., Meneveau N; Department of Cardiology, University Hospital Besançon, Besançon, France.; Marie and Louis Pasteur University, Besançon, France.; Sinergies Laboratory, Besançon, France., Monteleone P; Ascension Texas Cardiovascular, University of Texas Austin Dell School of Medicine, Austin., Montero-Cabezas JM; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Olivier CB; Department of Cardiology and Angiology, University Heart Center Freiburg Bad Krozingen, Bad Krozingen, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Park J; Nebraska Methodist Hospital, Omaha., Roik M; Department of Internal Medicine and Cardiology with Center for Venous Thromboembolism, Medical University of Warsaw, Warsaw, Poland., Sakhuja R; Division of Cardiology, Massachusetts General Hospital, Boston., Tego A; Department of Cardiology and Intensive Care Medicine, University Hospital Ostwestfalen-Lippe of Bielefeld University, Campus Klinikum Bielefeld, Bielefeld, Germany., Theurl M; Divisions of Cardiology and Angiology, University Hospital of Internal Medicine III, Medical University of Innsbruck, Innsbruck, Austria., Visveswaran G; Newark Beth Israel Medical Center, Newark, NJ., Vos JA; St. Antonius Ziekenhuis, Nieuwegein, the Netherlands., Young MN; Division of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, NH.; Geisel School of Medicine at Dartmouth, Hanover, NH., Asch FM; MedStar Health Research Institute, Washington, DC., Konstantinides SV; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.; Department of Cardiology, Democritus University of Thrace, Alexandroupolis, Greece.
Corporate Authors: HI-PEITHO Investigators
Source: The New England journal of medicine [N Engl J Med] 2026 May 28; Vol. 394 (20), pp. 1979-1990. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Adaptive Clinical Trial; Clinical Trial, Phase IV; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1533-4406
DOI:10.1056/NEJMoa2516567