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Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease.

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Title: Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease.
Authors: Santinelli L; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Pratuseviciute N; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Lange LM; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA., Kleinz T; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany., Brüggemann N; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany., Streubel-Gallasch L; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Möller M; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany., Zimprich A; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.; Department of Neurology, Medical University Vienna, Vienna, Austria., Brücke C; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.; Department of Neurology, Medical University Vienna, Vienna, Austria., Good JM; Division of Genetic Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Griebner N; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany., Padmanabhan S; The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA., Seibler P; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Bauer P; CENTOGENE GmbH, Rostock, Germany.; Pomeranian Medical University, Szczecin, Poland., Vandenberghe W; Laboratory for Parkinson Research, Department of Neurosciences, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., Sammler E; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.; National Institutes of Health, Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA., Klein C; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Borsche M; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.
Source: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2026 Jun; Vol. 41 (6), pp. 1605-1608. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Letter
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Santinelli+L%22">Santinelli L</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Pratuseviciute+N%22">Pratuseviciute N</searchLink>; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lange+LM%22">Lange LM</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kleinz+T%22">Kleinz T</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Brüggemann+N%22">Brüggemann N</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Streubel-Gallasch+L%22">Streubel-Gallasch L</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Möller+M%22">Möller M</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Zimprich+A%22">Zimprich A</searchLink>; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.; Department of Neurology, Medical University Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brücke+C%22">Brücke C</searchLink>; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.; Department of Neurology, Medical University Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Good+JM%22">Good JM</searchLink>; Division of Genetic Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Griebner+N%22">Griebner N</searchLink>; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Padmanabhan+S%22">Padmanabhan S</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Seibler+P%22">Seibler P</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+P%22">Bauer P</searchLink>; CENTOGENE GmbH, Rostock, Germany.; Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Vandenberghe+W%22">Vandenberghe W</searchLink>; Laboratory for Parkinson Research, Department of Neurosciences, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sammler+E%22">Sammler E</searchLink>; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.; National Institutes of Health, Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Borsche+M%22">Borsche M</searchLink>; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.; Section for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.
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  Data: <searchLink fieldCode="JN" term="%228610688%22">Movement disorders : official journal of the Movement Disorder Society</searchLink> [Mov Disord] 2026 Jun; Vol. 41 (6), pp. 1605-1608. <i>Date of Electronic Publication: </i>2026 Mar 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8610688 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1531-8257 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208853185%22">08853185 </searchLink><i>NLM ISO Abbreviation: </i>Mov Disord <i>Subsets: </i>MEDLINE; In Process
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        Text: English
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      – TitleFull: Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease.
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              Text: 2026 Jun
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