Spirocyclic β-lactone secondary metabolites modulate spliceosome function.

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Bibliographic Details
Title: Spirocyclic β-lactone secondary metabolites modulate spliceosome function.
Authors: Penton KE; Department of Chemistry, Vanderbilt University, Nashville, TN 37232., Bates SA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232., Thirman HL; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232.; Chemical & Physical Biology Program, Vanderbilt University, Nashville, TN 37232., Cameron CD; Department of Chemistry, Vanderbilt University, Nashville, TN 37232., Jurich C; Department of Chemistry, Vanderbilt University, Nashville, TN 37232., Grider-Hayes MJ; Department of Pediatrics-Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045., Jiang M; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232., Savona MR; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232., Yang ZJ; Department of Chemistry, Vanderbilt University, Nashville, TN 37232.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.; Vanderbilt University Data Science Institute, Nashville, TN 37235.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN 37232., Irish JM; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232.; Department of Pediatrics-Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045., Bachmann BO; Department of Chemistry, Vanderbilt University, Nashville, TN 37232.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 07; Vol. 123 (14), pp. e2518221123. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2518221123