Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2- locally-advanced or metastatic breast cancer.

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Bibliographic Details
Title: Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2- locally-advanced or metastatic breast cancer.
Authors: Liang J; Department of Translational Medicine, Genentech, South San Francisco, CA, USA. liang.jackson@gene.com., Ong C; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Heslop K; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Guan J; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Kameswaran V; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Daniel B; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Shi M; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Liang Y; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Giltnane JM; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Aimi J; Department of Translational Medicine, Genentech, South San Francisco, CA, USA., Chang CW; Department of Biostatistics, Genentech, South San Francisco, CA, USA., Gates MR; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA., Eng-Wong J; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA., Perez-Moreno P; Department of Product Development, Genentech, South San Francisco, CA, USA., Jhaveri KL; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA., Turner NC; Royal Marsden Hospital and Institute of Cancer Research, London, UK., Lim E; St Vincents Hospital, University of New South Wales and Garvan Institute, Sydney, NSW, Australia., Metcalfe C; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Moore HM; Department of Translational Medicine, Genentech, South San Francisco, CA, USA.
Source: Nature communications [Nat Commun] 2026 Apr 01; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-71233-1