View in EDS

Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2- locally-advanced or metastatic breast cancer.

Saved in:
Bibliographic Details
Title: Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2- locally-advanced or metastatic breast cancer.
Authors: Liang J; Department of Translational Medicine, Genentech, South San Francisco, CA, USA. liang.jackson@gene.com., Ong C; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Heslop K; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Guan J; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Kameswaran V; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Daniel B; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Shi M; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Liang Y; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA., Giltnane JM; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Aimi J; Department of Translational Medicine, Genentech, South San Francisco, CA, USA., Chang CW; Department of Biostatistics, Genentech, South San Francisco, CA, USA., Gates MR; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA., Eng-Wong J; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA., Perez-Moreno P; Department of Product Development, Genentech, South San Francisco, CA, USA., Jhaveri KL; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA., Turner NC; Royal Marsden Hospital and Institute of Cancer Research, London, UK., Lim E; St Vincents Hospital, University of New South Wales and Garvan Institute, Sydney, NSW, Australia., Metcalfe C; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Moore HM; Department of Translational Medicine, Genentech, South San Francisco, CA, USA.
Source: Nature communications [Nat Commun] 2026 Apr 01; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41917040
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER<superscript>+</superscript> HER2<superscript>-</superscript> locally-advanced or metastatic breast cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Liang+J%22">Liang J</searchLink>; Department of Translational Medicine, Genentech, South San Francisco, CA, USA. liang.jackson@gene.com.<br /><searchLink fieldCode="AU" term="%22Ong+C%22">Ong C</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Heslop+K%22">Heslop K</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guan+J%22">Guan J</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kameswaran+V%22">Kameswaran V</searchLink>; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Daniel+B%22">Daniel B</searchLink>; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Giltnane+JM%22">Giltnane JM</searchLink>; Department of Research Pathology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aimi+J%22">Aimi J</searchLink>; Department of Translational Medicine, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+CW%22">Chang CW</searchLink>; Department of Biostatistics, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gates+MR%22">Gates MR</searchLink>; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eng-Wong+J%22">Eng-Wong J</searchLink>; Department of Early Clinical Development, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perez-Moreno+P%22">Perez-Moreno P</searchLink>; Department of Product Development, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jhaveri+KL%22">Jhaveri KL</searchLink>; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Turner+NC%22">Turner NC</searchLink>; Royal Marsden Hospital and Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Lim+E%22">Lim E</searchLink>; St Vincents Hospital, University of New South Wales and Garvan Institute, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Metcalfe+C%22">Metcalfe C</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+HM%22">Moore HM</searchLink>; Department of Translational Medicine, Genentech, South San Francisco, CA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Apr 01; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41917040
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-71233-1
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2- locally-advanced or metastatic breast cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Liang J
      – PersonEntity:
          Name:
            NameFull: Ong C
      – PersonEntity:
          Name:
            NameFull: Heslop K
      – PersonEntity:
          Name:
            NameFull: Guan J
      – PersonEntity:
          Name:
            NameFull: Kameswaran V
      – PersonEntity:
          Name:
            NameFull: Daniel B
      – PersonEntity:
          Name:
            NameFull: Shi M
      – PersonEntity:
          Name:
            NameFull: Liang Y
      – PersonEntity:
          Name:
            NameFull: Giltnane JM
      – PersonEntity:
          Name:
            NameFull: Aimi J
      – PersonEntity:
          Name:
            NameFull: Chang CW
      – PersonEntity:
          Name:
            NameFull: Gates MR
      – PersonEntity:
          Name:
            NameFull: Eng-Wong J
      – PersonEntity:
          Name:
            NameFull: Perez-Moreno P
      – PersonEntity:
          Name:
            NameFull: Jhaveri KL
      – PersonEntity:
          Name:
            NameFull: Turner NC
      – PersonEntity:
          Name:
            NameFull: Lim E
      – PersonEntity:
          Name:
            NameFull: Metcalfe C
      – PersonEntity:
          Name:
            NameFull: Moore HM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1