EGFR-Targeted and MMP-Activated Membranolytic Peptides Kill Cancer Cells Specifically In Vitro and Reduce Tumor Growth In Vivo.

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Title: EGFR-Targeted and MMP-Activated Membranolytic Peptides Kill Cancer Cells Specifically In Vitro and Reduce Tumor Growth In Vivo.
Authors: Pramanik A; School of Medicine, University of Leeds, Leeds LS9 7TF, U.K.; Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh 201303, India., Booth A; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Kobza D; School of Medicine, University of Leeds, Leeds LS9 7TF, U.K.; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Brackenbury WJ; Jack Birch Cancer Research Unit, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, U.K., Connell SD; School of Physics and Astronomy and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Beales PA; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Hughes TA; School of Medicine, University of Leeds, Leeds LS9 7TF, U.K.; School of Science, Technology and Health, York St John University, York YO31 7EX, U.K.
Source: Molecular pharmaceutics [Mol Pharm] 2026 May 04; Vol. 23 (5), pp. 2955-2964. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1543-8392
DOI:10.1021/acs.molpharmaceut.5c01774