Uncovering BAP1 deubiquitination landscape enhances mechanism elucidation and therapeutic precision for BAP1-deficient pancancers.
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| Title: | Uncovering BAP1 deubiquitination landscape enhances mechanism elucidation and therapeutic precision for BAP1-deficient pancancers. |
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| Authors: | Hong JH; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Yong CH; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Department of Computer Science, National University of Singapore, Singapore 117417, Singapore., Heng HL; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore., Yao X; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore., Li Z; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Cancer Discovery Hub, National Cancer Center Singapore, Singapore 168583, Singapore., Sun Y; Department of Laboratory Medicine, School of Medicine, Guangzhou First People's Hospital, Guangzhou 510180, China., Wang P; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Xiao R; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Wang LC; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore.; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore., Chen J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Guan P; Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Singapore 138672, Singapore., Chu PL; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Hagihara T; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Ng SR; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore., Jusakul A; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand., Kongpetch S; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Nargund AM; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chu WC; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Ng CSY; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Sugiura M; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore 168582, Singapore., Kwek XY; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore 168582, Singapore., Pham NA; Princess Margaret Living Biobank, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada., Lin Z; Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Singapore 138672, Singapore., Ng CCY; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Cancer Discovery Hub, National Cancer Center Singapore, Singapore 168583, Singapore., Lim AH; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Cancer Discovery Hub, National Cancer Center Singapore, Singapore 168583, Singapore., Lee JY; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Cancer Discovery Hub, National Cancer Center Singapore, Singapore 168583, Singapore., Chan JY; Cancer Discovery Hub, National Cancer Center Singapore, Singapore 168583, Singapore.; Division of Medical Oncology, National Cancer Center Singapore, Singapore 168583, Singapore., Lim KS; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore., Liu W; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore., Teh BS; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX 77030, USA., Iqbal J; Department of Anatomical Pathology, Singapore General Hospital, Singapore 169856, Singapore., Klanrit P; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Loilome W; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Wai Meng Tai D; Division of Medical Oncology, National Cancer Center Singapore, Singapore 168583, Singapore.; Oncology Academic Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Brugarolas J; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 73590, USA.; Department of Internal Medicine, Hematology-Oncology Division, University of Texas Southwestern Medical Center, Dallas, TX 73590, USA., Li S; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore., Sobota RM; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore.; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore., Tan P; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore.; Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Singapore 138672, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore., Jha S; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.; Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA., Tan J; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.; Hainan Academy of Medical Science, Hainan Medical University, Haikou 571199, China.; Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510140, China., Teh BT; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore 169857, Singapore.; Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Center Singapore, Singapore 168583, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore.; Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Singapore 138672, Singapore. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Apr; Vol. 18 (843), pp. eadr6668. Date of Electronic Publication: 2026 Apr 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adr6668 |
