Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method.
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| Title: | Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method. |
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| Authors: | Koga T; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Sahara Y; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Ohtani T; Medicinal Chemistry Research Institute, Otsuka Pharmaceutical Co., Ltd. |
| Source: | The Journal of toxicological sciences [J Toxicol Sci] 2026; Vol. 51 (4), pp. 239-249. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989 (Electronic) Linking ISSN: 03881350 NLM ISO Abbreviation: J Toxicol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1880-3989 |
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| DOI: | 10.2131/jts.51.239 |
