Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method.
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| Title: | Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method. |
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| Authors: | Koga T; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Sahara Y; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Ohtani T; Medicinal Chemistry Research Institute, Otsuka Pharmaceutical Co., Ltd. |
| Source: | The Journal of toxicological sciences [J Toxicol Sci] 2026; Vol. 51 (4), pp. 239-249. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989 (Electronic) Linking ISSN: 03881350 NLM ISO Abbreviation: J Toxicol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41922267 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Koga+T%22">Koga T</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.<br /><searchLink fieldCode="AU" term="%22Sahara+Y%22">Sahara Y</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.<br /><searchLink fieldCode="AU" term="%22Ohtani+T%22">Ohtani T</searchLink>; Medicinal Chemistry Research Institute, Otsuka Pharmaceutical Co., Ltd. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227805798%22">The Journal of toxicological sciences</searchLink> [J Toxicol Sci] 2026; Vol. 51 (4), pp. 239-249. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Doku+Sayō+Kenkyūkai%22">Doku Sayō Kenkyūkai </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>7805798 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1880-3989 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203881350%22">03881350 </searchLink><i>NLM ISO Abbreviation: </i>J Toxicol Sci <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41922267 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2131/jts.51.239 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 239 Titles: – TitleFull: Evaluation of cytotoxicity of vesnarinone causing drug-induced agranulocytosis by a myeloperoxidase-like nonenzymatic metabolic approach using hypochlorous acid and application of the constructed assay method. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Koga T – PersonEntity: Name: NameFull: Sahara Y – PersonEntity: Name: NameFull: Ohtani T IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1880-3989 Numbering: – Type: volume Value: 51 – Type: issue Value: 4 Titles: – TitleFull: The Journal of toxicological sciences Type: main |
| ResultId | 1 |
