Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group.

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Title: Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group.
Authors: Hinojosa CA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta., Sun D; Brain Imaging and Analysis Center, Duke University, Durham, NC.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC., Russell C; Brain Imaging and Analysis Center, Duke University, Durham, NC.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC., Baird CL; Brain Imaging and Analysis Center, Duke University, Durham, NC.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC.; Department of Psychology, Pennsylvania State University, State College., Hussain A; Brain Imaging and Analysis Center, Duke University, Durham, NC.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC., Sendi M; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA.; Department of Psychiatry, Harvard Medical School, Boston., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA., Salminen LE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA., Olff M; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam.; ARQ National Psychotrauma Center, Diemen, the Netherlands., Frijling JL; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam.; De Viersprong Personality Disorders Institute, Amsterdam., Veltman DJ; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam.; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC Vrije Universiteit, Amsterdam., Koch SBJ; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam.; Donders Institute for Brain, Cognition, and Behavior, Center for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands., Nawijn L; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam., van Zuiden M; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC University of Amsterdam, Amsterdam.; Department of Clinical Psychology, Utrecht University, Utrecht, the Netherlands., Wang L; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing.; Department of Psychology, University of Chinese Academy of Sciences, Beijing., Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing.; Department of Psychology, University of Chinese Academy of Sciences, Beijing., Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing.; Department of Psychology, University of Chinese Academy of Sciences, Beijing., Stein DJ; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Ipser J; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Koopowitz SM; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Neria Y; Department of Psychiatry, Columbia University Medical Center, New York.; New York State Psychiatric Institute, New York., Zhu X; Department of Psychiatry, Columbia University Medical Center, New York.; New York State Psychiatric Institute, New York., Ravid O; New York State Psychiatric Institute, New York., Zilcha-Mano S; Department of Psychology, University of Haifa, Haifa, Israel., Lazarov A; Department of Psychiatry, Columbia University Medical Center, New York.; School of Psychological Sciences, Tel-Aviv University, Tel Aviv-Yafo, Israel., Suarez-Jimenez B; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY., Huggins AA; Department of Psychology, University of Arizona, Tucson., Ressler K; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA.; Department of Psychiatry, Harvard Medical School, Boston., Jovanovic T; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta.; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit., Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta., Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, the Netherlands.; Traumacentrum Beilen, GGZ Drenthe, the Netherlands., Sierk A; Research Division of Mind and Brain, University Medical Center Charité, Berlin., Manthey A; Research Division of Mind and Brain, University Medical Center Charité, Berlin., Walter H; Research Division of Mind and Brain, University Medical Center Charité, Berlin., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., van der Werff SJA; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., Vermeiren RRJM; Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands., Rektor I; Multimodal and Functional Neuroimaging Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Říha P; Multimodal and Functional Neuroimaging Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.; First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston.; Division of Women's Mental Health, McLean Hospital, Belmont, MA., Lebois LAM; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA.; Department of Psychiatry, Harvard Medical School, Boston., Baker JT; Department of Psychiatry, Harvard Medical School, Boston.; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA., King A; Department of Psychiatry, University of Michigan, Ann Arbor., Liberzon I; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan., Angstadt M; Department of Psychiatry, University of Michigan, Ann Arbor., Davenport ND; Minneapolis VA Health Care System, Minneapolis.; Department of Psychiatry, University of Minnesota, Minneapolis., Disner SG; Minneapolis VA Health Care System, Minneapolis.; Department of Psychiatry, University of Minnesota, Minneapolis., Sponheim SR; Minneapolis VA Health Care System, Minneapolis., Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Hofmann D; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany., Lu GM; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Qi R; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Wang X; Department of Psychiatry, University of Toledo, Toledo, OH., Kunch A; Department of Psychiatry, University of Toledo, Toledo, OH., Xie H; Department of Psychiatry, University of Toledo, Toledo, OH., Quidé Y; School of Psychology, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Randwick, Australia., El-Hage W; UMR1253, iBraiN, Université de Tours, Inserm, Tours, France., Lissek S; Department of Psychology, University of Minnesota, Minneapolis., Berg H; Department of Psychology, University of Minnesota, Minneapolis., Cisler J; Department of Psychiatry, University of Texas at Austin, Austin., Ross M; Northwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL., Herringa RJ; Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison., Grupe DW; Center for Healthy Minds, University of Wisconsin-Madison, Madison., Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison., Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison.; Department of Psychiatry, University of Wisconsin-Madison, Madison.; Department of Psychology, University of Wisconsin-Madison, Madison., Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee., deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee.; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee., Tomas CW; Department of Epidemiology, Institute of Health and Equity, Medical College of Wisconsin, Milwaukee.; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee., Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee., Feola B; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN., Urbano-Blackford J; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha., Olatunji BO; Department of Psychology, Vanderbilt University, Nashville, TN., May G; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas.; Department of Psychology and Neuroscience, Baylor University, Waco, TX.; Veterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Waco, TX., Nelson SM; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas.; Department of Psychology and Neuroscience, Baylor University, Waco, TX.; Veterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Waco, TX., Gordon EM; Department of Radiology, Washington University School of Medicine, St. Louis., Abdallah CG; Department of Psychiatry, Baylor College of Medicine, Houston.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT., Lanius R; Department of Neuroscience, Western University, London.; Department of Psychiatry, Western University, London., Densmore M; Department of Psychiatry, Western University, London., Théberge J; Department of Psychiatry, Western University, London., Neufeld RWJ; Department of Psychiatry, Western University, London., Baugh LA; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion.; Center for Brain and Behavior Research, University of South Dakota, Vermillion.; Sioux Falls VA Health Care System, Sioux Falls, SD., Simons RM; Center for Brain and Behavior Research, University of South Dakota, Vermillion.; Department of Psychology, University of South Dakota, Vermillion., Simons JS; Sioux Falls VA Health Care System, Sioux Falls, SD.; Department of Psychology, University of South Dakota, Vermillion., Magnotta VA; Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City., Fercho KA; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion.; Center for Brain and Behavior Research, University of South Dakota, Vermillion.; Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City., Elman J; Department of Psychiatry, University of California San Diego, La Jolla.; Stein Institute for Research on Aging and Center for Healthy Aging, University of California San Diego, La Jolla., Panizzon M; Department of Psychiatry, University of California San Diego, La Jolla., Franz C; Department of Psychiatry, University of California, San Diego, La Jolla.; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla., Lyons MJ; Department of Psychological and Brain Sciences, Boston University, Boston., Kremen W; Department of Psychiatry, University of California, San Diego, La Jolla.; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA., McLaughin KA; Department of Psychology, Harvard University, Cambridge, MA., Peverill M; Department of Psychology, University of Washington, Seattle., Sambrook K; Department of Radiology, University of Washington, Seattle., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta., Morey RA; Brain Imaging and Analysis Center, Duke University, Durham, NC.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta.
Source: The American journal of psychiatry [Am J Psychiatry] 2026 May 01; Vol. 183 (5), pp. 333-342. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1535-7228
DOI:10.1176/appi.ajp.20250062