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Quantitative imaging of schwannoma captures heterogeneity and accelerates preclinical testing, revealing distinct impacts of targeted therapies.

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Title: Quantitative imaging of schwannoma captures heterogeneity and accelerates preclinical testing, revealing distinct impacts of targeted therapies.
Authors: Wright EA; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA., Vitte J; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA., Veiga SI; Center for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA., Bushnell SE; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA., Movsessian CE; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA., Zhang Y; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA., Curtis J; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA., Corcoran RB; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA., Stott SL; Center for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA., Giovannini M; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA., Chiasson-MacKenzie C; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA., McClatchey AI; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 28. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Quantitative imaging of schwannoma captures heterogeneity and accelerates preclinical testing, revealing distinct impacts of targeted therapies.
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  Data: <searchLink fieldCode="AU" term="%22Wright+EA%22">Wright EA</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.<br /><searchLink fieldCode="AU" term="%22Vitte+J%22">Vitte J</searchLink>; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA.<br /><searchLink fieldCode="AU" term="%22Veiga+SI%22">Veiga SI</searchLink>; Center for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA.<br /><searchLink fieldCode="AU" term="%22Bushnell+SE%22">Bushnell SE</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.<br /><searchLink fieldCode="AU" term="%22Movsessian+CE%22">Movsessian CE</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.<br /><searchLink fieldCode="AU" term="%22Curtis+J%22">Curtis J</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.<br /><searchLink fieldCode="AU" term="%22Corcoran+RB%22">Corcoran RB</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.<br /><searchLink fieldCode="AU" term="%22Stott+SL%22">Stott SL</searchLink>; Center for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA.<br /><searchLink fieldCode="AU" term="%22Giovannini+M%22">Giovannini M</searchLink>; Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA.<br /><searchLink fieldCode="AU" term="%22Chiasson-MacKenzie+C%22">Chiasson-MacKenzie C</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.<br /><searchLink fieldCode="AU" term="%22McClatchey+AI%22">McClatchey AI</searchLink>; Massachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Boston, MA 02114 USA.
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              Text: 2026 Mar 28
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