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Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease.

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Title: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease.
Authors: Gupta AO; University of Minnesota, Minneapolis., Sharma A; St. Jude Children's Research Hospital, Memphis, TN., Frangoul H; Sarah Cannon Research Institute, Nashville.; TriStar Centennial Children's Hospital, Nashville., Kanter J; University of Alabama at Birmingham, Birmingham., Mapara MY; Columbia University Medical Center, New York., Dalal J; Rainbow Babies and Children's Hospital, Cleveland., Alavi A; Henry Ford Health System, Detroit., Jaroscak JJ; Medical University of South Carolina, Charleston., Ayala E; Mayo Clinic, Jacksonville, FL., DiPersio JF; Washington University, St. Louis., Ziga ED; University of Miami, Miami., Eapen M; Medical College of Wisconsin, Milwaukee., Rifkin-Zenenberg S; Hackensack University Medical Center, Hackensack, NJ., Minella AC; Beam Therapeutics, Cambridge, MA., Chen Y; Beam Therapeutics, Cambridge, MA., Chesler S; Beam Therapeutics, Cambridge, MA., Ambati S; Beam Therapeutics, Cambridge, MA., Bowman TS; Beam Therapeutics, Cambridge, MA., Habtemariam B; Beam Therapeutics, Cambridge, MA., Joseney-Antoine M; Beam Therapeutics, Cambridge, MA., Chockalingam PS; Beam Therapeutics, Cambridge, MA., Lin L; Beam Therapeutics, Cambridge, MA., Goyal S; Beam Therapeutics, Cambridge, MA., Simon A; Beam Therapeutics, Cambridge, MA., Thompson AA; Children's Hospital of Philadelphia, Philadelphia., Heeney MM; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston.
Corporate Authors: BEACON Investigators
Source: The New England journal of medicine [N Engl J Med] 2026 May 07; Vol. 394 (18), pp. 1824-1835. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease.
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  Data: <searchLink fieldCode="AU" term="%22Gupta+AO%22">Gupta AO</searchLink>; University of Minnesota, Minneapolis.<br /><searchLink fieldCode="AU" term="%22Sharma+A%22">Sharma A</searchLink>; St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Frangoul+H%22">Frangoul H</searchLink>; Sarah Cannon Research Institute, Nashville.; TriStar Centennial Children's Hospital, Nashville.<br /><searchLink fieldCode="AU" term="%22Kanter+J%22">Kanter J</searchLink>; University of Alabama at Birmingham, Birmingham.<br /><searchLink fieldCode="AU" term="%22Mapara+MY%22">Mapara MY</searchLink>; Columbia University Medical Center, New York.<br /><searchLink fieldCode="AU" term="%22Dalal+J%22">Dalal J</searchLink>; Rainbow Babies and Children's Hospital, Cleveland.<br /><searchLink fieldCode="AU" term="%22Alavi+A%22">Alavi A</searchLink>; Henry Ford Health System, Detroit.<br /><searchLink fieldCode="AU" term="%22Jaroscak+JJ%22">Jaroscak JJ</searchLink>; Medical University of South Carolina, Charleston.<br /><searchLink fieldCode="AU" term="%22Ayala+E%22">Ayala E</searchLink>; Mayo Clinic, Jacksonville, FL.<br /><searchLink fieldCode="AU" term="%22DiPersio+JF%22">DiPersio JF</searchLink>; Washington University, St. Louis.<br /><searchLink fieldCode="AU" term="%22Ziga+ED%22">Ziga ED</searchLink>; University of Miami, Miami.<br /><searchLink fieldCode="AU" term="%22Eapen+M%22">Eapen M</searchLink>; Medical College of Wisconsin, Milwaukee.<br /><searchLink fieldCode="AU" term="%22Rifkin-Zenenberg+S%22">Rifkin-Zenenberg S</searchLink>; Hackensack University Medical Center, Hackensack, NJ.<br /><searchLink fieldCode="AU" term="%22Minella+AC%22">Minella AC</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Chesler+S%22">Chesler S</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Ambati+S%22">Ambati S</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Bowman+TS%22">Bowman TS</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Habtemariam+B%22">Habtemariam B</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Joseney-Antoine+M%22">Joseney-Antoine M</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Chockalingam+PS%22">Chockalingam PS</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Goyal+S%22">Goyal S</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Simon+A%22">Simon A</searchLink>; Beam Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Thompson+AA%22">Thompson AA</searchLink>; Children's Hospital of Philadelphia, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Heeney+MM%22">Heeney MM</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston.
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  Data: <searchLink fieldCode="JN" term="%220255562%22">The New England journal of medicine</searchLink> [N Engl J Med] 2026 May 07; Vol. 394 (18), pp. 1824-1835. <i>Date of Electronic Publication: </i>2026 Apr 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Massachusetts+Medical+Society%22">Massachusetts Medical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0255562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1533-4406 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200284793%22">00284793 </searchLink><i>NLM ISO Abbreviation: </i>N Engl J Med <i>Subsets: </i>MEDLINE
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        Value: 10.1056/NEJMoa2504835
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      – Code: eng
        Text: English
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        StartPage: 1824
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      – TitleFull: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease.
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              Text: 2026 May 07
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