Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.

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Title: Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.
Authors: Chung D; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Otsuka Y; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Kim E; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Ullah S; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Kennedy NM; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Ngo KH; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Kang J; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Tomlinson R; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Alejandro B; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Barnaby K; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Miller J; Center for Predictive Medicine, Department of Microbiology Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America., Shumate J; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Teo CF; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Tan YB; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Chew CS; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Kang C; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore., Scampavia L; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Spicer TP; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America., Bannister TD; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2026 Apr 03; Vol. 22 (4), pp. e1013609. Date of Electronic Publication: 2026 Apr 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1553-7374
DOI:10.1371/journal.ppat.1013609