Predictors of poor treatment tolerability in older patients receiving fluoropyrimidine-based chemotherapy: A prospective cohort study.

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Title: Predictors of poor treatment tolerability in older patients receiving fluoropyrimidine-based chemotherapy: A prospective cohort study.
Authors: Baltussen JC; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: j.c.baltussen@lumc.nl., Knikman JE; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., de Glas NA; Department of Oncology, Helse Førde, Førde, Norway., de With M; Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands; Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, the Netherlands., Baars A; Department of Medical Oncology, Hospital Gelderse Vallei, Ede, the Netherlands., Creemers GJ; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Droogendijk HJ; Department of Internal Medicine, Bravis Hospital, Roosendaal, the Netherlands., Fiets E; Department of Internal Medicine, Medical Center Leeuwarden, Leeuwarden, the Netherlands., van Iersel-Valkenburg L; Department of Internal Medicine, Division of Medical Oncology, Maastricht University Medical Centre, Maastricht, the Netherlands., Mandigers CMPW; Department of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., Imholz ALT; Department of Internal Medicine, Deventer Hospital, Deventer, the Netherlands., van de Poel MHW; Department of Internal Medicine, Laurentius Hospital, Roermond, the Netherlands., Jeurissen FJF; Department of Medical Oncology, Haaglanden Medisch Centrum, the Hague, the Netherlands., Wymenga M; Department of Oncology, Medisch Spectrum Twente, Enschede, the Netherlands., Nieboer P; Department of Internal Medicine, Wilhelmina Hospital Assen, Assen, the Netherlands., Tigges T; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Wesseling E; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Schellens JHM; Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Mathijssen RHJ; Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Mooijaart SP; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands; LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, the Netherlands., Cats A; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastrointestinal Oncology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Portielje JEA; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Source: Journal of geriatric oncology [J Geriatr Oncol] 2026 May; Vol. 17 (4), pp. 102963. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101534770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-4076 (Electronic) Linking ISSN: 18794068 NLM ISO Abbreviation: J Geriatr Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-4076
DOI:10.1016/j.jgo.2026.102963