Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials.

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Title: Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials.
Authors: Williamson C; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. carolyn.williamson@uct.ac.za.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa. carolyn.williamson@uct.ac.za.; National Health Laboratory Service, Cape Town, South Africa. carolyn.williamson@uct.ac.za., Moodley C; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Magaret CA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Giorgi EE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Rolland M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Westfall DH; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Microbiology, University of Washington, Seattle, WA, USA., Yssel A; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Deng W; Department of Microbiology, University of Washington, Seattle, WA, USA., Rossenkhan R; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Mkhize NN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Chen L; Department of Microbiology, University of Washington, Seattle, WA, USA., Zhao H; Department of Microbiology, University of Washington, Seattle, WA, USA., Bhattacharya T; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA., Pankow A; Department of Microbiology, University of Washington, Seattle, WA, USA.; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden.; Department of Microbiology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA., Murrell B; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden., York T; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Gwashu-Nyangiwe A; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Ndabambi N; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Thebus R; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Cohen P; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Lambson B; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kaldine H; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bhebhe S; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Juraska M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bai H; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Miner MD; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Ludwig J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Molitor C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Beaume N; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Matten D; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Zhang L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Reeves DB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Mayer B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Karuna ST; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Hural JA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Morris L; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Montefiori D; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Bumgarner RE; Department of Microbiology, University of Washington, Seattle, WA, USA., Moore PL; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SAMRC Antibody Immunity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Edlefsen PT; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Edupuganti S; Emory University, Atlanta, GA, USA., Mgodi N; University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Cohen MS; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Mullins JI; Department of Microbiology, University of Washington, Seattle, WA, USA. jmullins@uw.edu.; Department of Medicine, University of Washington, Seattle, WA, USA. jmullins@uw.edu.; Department of Global Health, University of Washington, Seattle, WA, USA. jmullins@uw.edu.
Source: Nature communications [Nat Commun] 2026 Apr 03; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-70888-0