Downregulation of L-type Ca2+ current in patients with atrial fibrillation results from altered channel gating and disruption of membrane microdomains.

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Title: Downregulation of L-type Ca2+ current in patients with atrial fibrillation results from altered channel gating and disruption of membrane microdomains.
Authors: Balycheva M; National Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Reilly-O'Donnell B; National Heart and Lung Institute, Imperial College London, United Kingdom., Alvarez-Laviada A; National Heart and Lung Institute, Imperial College London, United Kingdom., Zhang K; Department of Biomedical Engineering Johns Hopkins University, Baltimore, Maryland., Mazzola M; National Heart and Lung Institute, Imperial College London, United Kingdom; Humanitas Clinical and Research Center, Rozzano, Milan, Italy., Sanchez-Alonso JL; National Heart and Lung Institute, Imperial College London, United Kingdom., Lucarelli C; National Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy., Medvedev RY; National Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Molina CE; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Schobesberger S; National Heart and Lung Institute, Imperial College London, United Kingdom., Diakonov I; National Heart and Lung Institute, Imperial College London, United Kingdom., Wright PT; National Heart and Lung Institute, Imperial College London, United Kingdom; School of Life and Health Sciences, University of Roehampton, London, United Kingdom., Poulet CE; National Heart and Lung Institute, Imperial College London, United Kingdom., Bork NI; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Trayanova NA; Department of Biomedical Engineering Johns Hopkins University, Baltimore, Maryland; Department of Medicine, Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, Maryland., Faggian G; University of Verona, School of Medicine, Verona, Italy., Punjabi P; National Heart and Lung Institute, Imperial College London, United Kingdom; Department of Cardiothoracic Surgery, Hammersmith Hospital, National Heart and Lung Institute, Imperial College London, United Kingdom., Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Glukhov AV; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: aglukhov@medicine.wisc.edu., Gorelik J; National Heart and Lung Institute, Imperial College London, United Kingdom. Electronic address: j.gorelik@ic.ac.uk.
Source: Heart rhythm [Heart Rhythm] 2026 Apr 01. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1556-3871
DOI:10.1016/j.hrthm.2026.03.1953