Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style.

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Title: Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style.
Authors: Kranz TM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., McNeill RV; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany., Jacob CP; Department of Psychiatry and Psychotherapy, Medius Hospital of Kirchheim, Kirchheim unter Teck, Germany., Ahrens KF; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Neumann RJ; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Plichta MM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Kollmann B; Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center, Mainz, Germany.; Leibniz Institute for Resilience Research, Mainz, Germany., Streit F; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany., Tüscher O; Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center, Mainz, Germany.; Leibniz Institute for Resilience Research, Mainz, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Martin Luther University Halle-Wittenberg (MLU) & German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Halle, Germany., Lieb K; Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center, Mainz, Germany., Weber H; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany., Romanos M; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany., Lesch KP; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Kittel-Schneider S; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland., Ziegler GC; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany. ziegler_g@ukw.de.; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany. ziegler_g@ukw.de.
Source: Translational psychiatry [Transl Psychiatry] 2026 Apr 04; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-04008-3