Experimental assessment of AI-based interactome mapping.
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| Title: | Experimental assessment of AI-based interactome mapping. |
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| Authors: | Lambourne L; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yadav A; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang Y; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Desbuleux A; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Viral Interactomes, Computational and Molecular Biology Unit, GIGA Institute, University of Liège, Liège, Belgium., Kim DK; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada., Laval F; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Viral Interactomes, Computational and Molecular Biology Unit, GIGA Institute, University of Liège, Liège, Belgium.; TERRA Teaching and Research Centre, University of Liège, Gembloux, Belgium., Spirohn-Fitzgerald K; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Cafarelli T; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Pons C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain., Kovács IA; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Network Science Institute, Northeastern University, Boston, MA, USA.; Department of Physics and Astronomy, Northwestern University, Evanston, IL, USA.; Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL, USA.; NSF-Simons National Institute for Theory and Mathematics in Biology, Chicago, IL, USA., Jailkhani N; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Schlabach S; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., De Ridder D; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Luck K; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Botchkarev VV Jr; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Debnath O; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Bian W; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Shen Y; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yang Z; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Mee MW; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Helmy M; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada., Jacob Y; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Unité de Génétique Moléculaire des Virus à ARN (GMVR), Département de Virologie, Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Paris, France.; Université Paris Diderot, Paris, France., Lemmens I; Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.; Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Rolland T; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., McClain GG; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Coté AG; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada., Gebbia M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada., Kishore N; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada., Knapp JJ; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada., Mellor JC; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada.; seqWell, Beverly, MA, USA., Memisoglu G; Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA., Reimand J; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Tavernier J; Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.; Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Cusick ME; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Zhong Q; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Sciences, Wright State University, Dayton, OH, USA., Aloy P; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Hao T; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Charloteaux B; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Roth FP; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, ON, Canada.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., De Las Rivas J; Cancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC)/University of Salamanca (USAL), and Instituto de Investigacion Biomedica de Salamanca (IBSAL), Salamanca, Spain.; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Falter-Braun P; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. pascal.falter-braun@helmholtz-munich.de.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. pascal.falter-braun@helmholtz-munich.de.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. pascal.falter-braun@helmholtz-munich.de.; Institute of Network Biology (INET), Molecular Targets and Therapeutics Center (MTTC), Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany. pascal.falter-braun@helmholtz-munich.de.; Microbe-Host Interactions, Faculty of Biology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. pascal.falter-braun@helmholtz-munich.de., Hill DE; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. david_hill@dfci.harvard.edu.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. david_hill@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. david_hill@dfci.harvard.edu., Calderwood MA; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. michael_calderwood@dfci.harvard.edu.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. michael_calderwood@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. michael_calderwood@dfci.harvard.edu., Twizere JC; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. jean-claude.twizere@uliege.be.; Laboratory of Viral Interactomes, Computational and Molecular Biology Unit, GIGA Institute, University of Liège, Liège, Belgium. jean-claude.twizere@uliege.be.; TERRA Teaching and Research Centre, University of Liège, Gembloux, Belgium. jean-claude.twizere@uliege.be.; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE. jean-claude.twizere@uliege.be., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. marc_vidal@dfci.harvard.edu.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. marc_vidal@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. marc_vidal@dfci.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2026 Apr 04; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-70942-x |
