The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.

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Title: The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.
Authors: Evangelakos I; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Verkade E; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Rohde JK; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zaufel A; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., Vargek M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., Heine M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Worthmann A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Graute S; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Manka Fuh M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gunasekaran K; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kumari M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwinge D; Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., von Bergen M; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Rolle-Kampczyk U; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Engelmann B; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Breinbauer R; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria., Fuerst R; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria., Saleem U; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., de Boer JF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Schlein C; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kuipers F; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Moustafa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address: tarek.moustafa@medunigraz.at., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: heeren@uke.de.
Source: Molecular metabolism [Mol Metab] 2026 May; Vol. 107, pp. 102363. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2212-8778
DOI:10.1016/j.molmet.2026.102363