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The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.

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Title: The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.
Authors: Evangelakos I; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Verkade E; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Rohde JK; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zaufel A; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., Vargek M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., Heine M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Worthmann A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Graute S; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Manka Fuh M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gunasekaran K; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kumari M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwinge D; Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., von Bergen M; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Rolle-Kampczyk U; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Engelmann B; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany., Breinbauer R; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria., Fuerst R; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria., Saleem U; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., de Boer JF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Schlein C; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kuipers F; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Moustafa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address: tarek.moustafa@medunigraz.at., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: heeren@uke.de.
Source: Molecular metabolism [Mol Metab] 2026 May; Vol. 107, pp. 102363. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Evangelakos+I%22">Evangelakos I</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Verkade+E%22">Verkade E</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rohde+JK%22">Rohde JK</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zaufel+A%22">Zaufel A</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Vargek+M%22">Vargek M</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Heine+M%22">Heine M</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Worthmann+A%22">Worthmann A</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Graute+S%22">Graute S</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Manka+Fuh+M%22">Manka Fuh M</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gunasekaran+K%22">Gunasekaran K</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kumari+M%22">Kumari M</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwinge+D%22">Schwinge D</searchLink>; Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bergen+M%22">von Bergen M</searchLink>; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rolle-Kampczyk+U%22">Rolle-Kampczyk U</searchLink>; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Engelmann+B%22">Engelmann B</searchLink>; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Breinbauer+R%22">Breinbauer R</searchLink>; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.<br /><searchLink fieldCode="AU" term="%22Fuerst+R%22">Fuerst R</searchLink>; Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.<br /><searchLink fieldCode="AU" term="%22Saleem+U%22">Saleem U</searchLink>; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Boer+JF%22">de Boer JF</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schlein+C%22">Schlein C</searchLink>; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+A%22">Hansen A</searchLink>; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Scheja+L%22">Scheja L</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuipers+F%22">Kuipers F</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moustafa+T%22">Moustafa T</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address: tarek.moustafa@medunigraz.at.<br /><searchLink fieldCode="AU" term="%22Heeren+J%22">Heeren J</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: heeren@uke.de.
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