Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma.
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| Title: | Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma. |
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| Authors: | Wiemers TC; Department of Visceral, Transplantation, Vascular and Thoracic Surgery University Hospital Leipzig Leipzig Germany.; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany.; Innovation Center Computer Assisted Surgery (ICCAS) University Hospital Leipzig Leipzig Germany., Rade M; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany., Grieb N; Innovation Center Computer Assisted Surgery (ICCAS) University Hospital Leipzig Leipzig Germany., Ferle M; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany.; Innovation Center Computer Assisted Surgery (ICCAS) University Hospital Leipzig Leipzig Germany.; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany.; Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) University of Leipzig Leipzig Germany., Dermendzhiev T; Department of Diagnostic and Interventional Radiology University Hospital Leipzig Leipzig Germany., Fandrei D; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany.; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany., Born P; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Fischer L; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Seiffert S; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Grahnert A; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Friedrich M; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Baber R; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics University Hospital Leipzig Leipzig Germany.; Leipzig Medical Biobank University of Leipzig Leipzig Germany., Kreuz M; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany., Metzeler KH; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Herling M; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Herling CD; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Jentzsch M; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Franke GN; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Boldt A; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Neumuth T; Innovation Center Computer Assisted Surgery (ICCAS) University Hospital Leipzig Leipzig Germany., Shah UA; Myeloma Service Memorial Sloan Kettering Cancer Center New York New York United States., Köhl U; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany.; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Reiche K; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany.; Institute of Clinical Immunology, Medical Faculty University of Leipzig Leipzig Saxony Germany., Denecke T; Department of Diagnostic and Interventional Radiology University Hospital Leipzig Leipzig Germany., Platzbecker U; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Vučinić V; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany., Meyer HJ; Department of Diagnostic and Interventional Radiology University Hospital Leipzig Leipzig Germany., Merz M; Department of Hematology, Hemostaseology, Cellular Therapy and Infectiology University Hospital Leipzig Leipzig Germany.; Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany.; Myeloma Service Memorial Sloan Kettering Cancer Center New York New York United States. |
| Source: | HemaSphere [Hemasphere] 2026 Mar 24; Vol. 10 (3), pp. e70314. Date of Electronic Publication: 2026 Mar 24 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2572-9241 |
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| DOI: | 10.1002/hem3.70314 |
