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Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.

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Title: Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.
Authors: Karabova MK; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Del Ser-Badia A; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Hedegaard A; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Washer SJ; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Baykam Z; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., O'Brien DP; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vendrell I; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hester SS; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fischer R; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Johnson E; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Melia CE; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Matthews-Palmer TRS; Central Oxford Structural Molecular Imaging Centre, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; Current affiliation: Division of Structural Biology, The Institute of Cancer Research (ICR), London, UK., Matadeen R; Central Oxford Structural Molecular Imaging Centre, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK., Santambrogio A; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Metrick MA 2nd; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Keeling S; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK., Cheam KAX; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK., McEwan WA; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK., Kosik KS; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Day TA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, USA., James WS; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Cowley SA; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71337.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.
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  Data: <searchLink fieldCode="AU" term="%22Karabova+MK%22">Karabova MK</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Del+Ser-Badia+A%22">Del Ser-Badia A</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hedegaard+A%22">Hedegaard A</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Washer+SJ%22">Washer SJ</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Baykam+Z%22">Baykam Z</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22O'Brien+DP%22">O'Brien DP</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Vendrell+I%22">Vendrell I</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hester+SS%22">Hester SS</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fischer+R%22">Fischer R</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Johnson+E%22">Johnson E</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Melia+CE%22">Melia CE</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Matthews-Palmer+TRS%22">Matthews-Palmer TRS</searchLink>; Central Oxford Structural Molecular Imaging Centre, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; Current affiliation: Division of Structural Biology, The Institute of Cancer Research (ICR), London, UK.<br /><searchLink fieldCode="AU" term="%22Matadeen+R%22">Matadeen R</searchLink>; Central Oxford Structural Molecular Imaging Centre, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Santambrogio+A%22">Santambrogio A</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Metrick+MA+2nd%22">Metrick MA 2nd</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vendruscolo+M%22">Vendruscolo M</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Keeling+S%22">Keeling S</searchLink>; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cheam+KAX%22">Cheam KAX</searchLink>; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McEwan+WA%22">McEwan WA</searchLink>; UK Dementia Research Institute at the University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kosik+KS%22">Kosik KS</searchLink>; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.<br /><searchLink fieldCode="AU" term="%22Day+TA%22">Day TA</searchLink>; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22James+WS%22">James WS</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cowley+SA%22">Cowley SA</searchLink>; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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