Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction.

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Title: Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction.
Authors: Landsteiner I; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Stolze LK; Vanderbilt University Medical Center, Nashville, TN., Peterson TE; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN., Perry A; Vanderbilt University Medical Center, Nashville, TN., Lin P; Vanderbilt University Medical Center, Nashville, TN., Sheng Q; Vanderbilt University Medical Center, Nashville, TN., Zhao S; Vanderbilt University Medical Center, Nashville, TN., Amancherla K; Vanderbilt University Medical Center, Nashville, TN., Mi MY; Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Ikoma T; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Cohen LP; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Giverts I; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Campain J; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Lima JAC; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Gerszten R; Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA., Tracy R; University of Vermont, Burlington, VT., Durda P; University of Vermont, Burlington, VT., Wood AC; Baylor College of Medicine, Houston, TX., Malhotra R; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Clish C; Broad Institute of Harvard and MIT, Cambridge, MA., Nayor M; Sections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA., Gamazon ER; Vanderbilt University Medical Center, Nashville, TN., Shah RV; Vanderbilt University Medical Center, Nashville, TN., Lewis GD; Cardiology Division, Department of Medicine, Massachusetts General Brigham Heart and Vascular Institute, Boston, MA.
Source: Circulation [Circulation] 2026 Apr 07. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.125.077579