Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization.
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| Title: | Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization. |
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| Authors: | Moldaver S; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Thibeault PE; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Robitaille M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.; School of Pharmacy and Pharmaceutical Sciences, University of Queensland, Woolloongabba, QLD, Australia., Au A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Lin S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., MacLeod G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Junge HJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.; Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota, Minneapolis, MN, USA., Gammons MV; Cambridge Institute of Medical Research, Department of Medical Genomics, University of Cambridge, Cambridge, UK., Yip CM; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada., Angers S; Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. |
| Source: | Science signaling [Sci Signal] 2026 Apr 07; Vol. 19 (932), pp. eaec0204. Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1937-9145 |
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| DOI: | 10.1126/scisignal.aec0204 |
