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Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial.

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Title: Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial.
Authors: Watts GF; School of Medicine, University of Western Australia and Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia. gerald.watts@uwa.edu.au., Scott R; New Zealand Clinical Research, Christchurch, New Zealand., Sullivan D; Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Baker J; Middlemore Hospital, Auckland, New Zealand., Clifton P; Royal Adelaide Hospital, Adelaide, South Australia, Australia., Hamilton J; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA., Given B; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA., Melquist S; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA., Zhou R; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA., Gaudet D; Dept of Medicine, Université de Montréal, and ECOGENE 21 QC, Montréal, Quebec, Canada., Goldberg IJ; NYU School of Medicine, NYU Langone Health, New York City, NY, USA., Knowles JW; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Leeper NJ; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Hegele RA; Robarts Research Institute, London, Ontario, Canada., Ballantyne CM; Baylor College of Medicine and the Texas Heart Institute, Houston, TX, USA.
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1432-1443. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Watts+GF%22">Watts GF</searchLink>; School of Medicine, University of Western Australia and Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia. gerald.watts@uwa.edu.au.<br /><searchLink fieldCode="AU" term="%22Scott+R%22">Scott R</searchLink>; New Zealand Clinical Research, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Sullivan+D%22">Sullivan D</searchLink>; Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Baker+J%22">Baker J</searchLink>; Middlemore Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Clifton+P%22">Clifton P</searchLink>; Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Hamilton+J%22">Hamilton J</searchLink>; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Given+B%22">Given B</searchLink>; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melquist+S%22">Melquist S</searchLink>; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; Arrowhead Pharmaceuticals Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gaudet+D%22">Gaudet D</searchLink>; Dept of Medicine, Université de Montréal, and ECOGENE 21 QC, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Goldberg+IJ%22">Goldberg IJ</searchLink>; NYU School of Medicine, NYU Langone Health, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+JW%22">Knowles JW</searchLink>; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leeper+NJ%22">Leeper NJ</searchLink>; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hegele+RA%22">Hegele RA</searchLink>; Robarts Research Institute, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ballantyne+CM%22">Ballantyne CM</searchLink>; Baylor College of Medicine and the Texas Heart Institute, Houston, TX, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1432-1443. <i>Date of Electronic Publication: </i>2026 Apr 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE
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