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Phosphorylated mTOR immunohistochemistry-guided use of temsirolimus in recurrent IDH-wildtype glioblastoma: a real-world retrospective series.

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Title: Phosphorylated mTOR immunohistochemistry-guided use of temsirolimus in recurrent IDH-wildtype glioblastoma: a real-world retrospective series.
Authors: Teresa Schmidt; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Surau M; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Oster C; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kizina K; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Grieger J; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Cappello G; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Jekel L; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Lazaridis L; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Ahmadipour Y; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioural Sciences (C-TNBS),, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Rauschenbach L; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioural Sciences (C-TNBS),, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Guberina N; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Pöttgen C; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Keyvani K; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Stuschke M; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kleinschnitz C; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany., Sure U; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioural Sciences (C-TNBS),, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Junker A; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Glas M; Department of Neurology and Neurooncology, St. Marien Hospital, Lünen, Germany.; Department of Neurooncology, Center for Neurology, University Hospital Bonn, Bonn, Germany., Sied Kebir; Department of Neurology and Center for Translational Neuro- and Behavioural Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Hufelandstr 55, 45147, Essen, Germany. sied.kebir@uk-essen.de.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany. sied.kebir@uk-essen.de.
Source: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2026 Apr 07; Vol. 152 (4). Date of Electronic Publication: 2026 Apr 07.
Publication Type: Letter
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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ISSN:1432-1335
DOI:10.1007/s00432-026-06464-2