Prevention of oral mucositis in patients undergoing cancer chemotherapy using betamethasone mouthwash: A multicenter randomized controlled trial protocol.

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Title: Prevention of oral mucositis in patients undergoing cancer chemotherapy using betamethasone mouthwash: A multicenter randomized controlled trial protocol.
Authors: Soutome S; Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Center for Clinical and Translational Research, Toyama University Hospital, Toyama, Japan., Hamada T; Department of Oral and Maxillofacial Surgery, Social Medical Corporation Hakuaikai Sagara Hospital, Kagoshima, Japan., Nishi H; Department of General Dentistry, Hiroshima University Hospital, Hiroshima, Japan., Iwata E; Department of Oral and Maxillofacial Surgery, Kakogawa Central City Hospital, Hyogo, Japan., Nakahara H; Department of Dentistry and Oral Surgery, Osaka Metropolitan University Hospital, Osaka, Japan., Yamamoto T; Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Matsumura T; Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Wakayama, Japan., Nishikawa M; Department of Dentistry and Oral Surgery, Nishichita General Hospital, Aichi, Japan., Tomihara K; Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan., Ueki K; Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School, University of Yamanashi, Yamanashi, Japan., Noda M; Department of Endodontics, School of Dentistry, Faculties and Graduate Schools, Iwate Medical University, Iwate, Japan., Shimanishi M; Department of Dental and Oral Surgery, Oji General Hospital, Hokkaido, Japan., Funahara M; School of Oral Health Sciences Faculty of Dentistry, Kyushu Dental University, Fukuoka, Japan., Kawahara M; Laboratory of Clinical Pharmacy, School of Pharmacy, Aichi Gakuin University, Aichi, Japan., Yamamura Y; Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan., Matsuda S; Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Yoshida K; Department of Drug Safety and Risk Management, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Kanazawa S; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Otsuji M; Dentistry/Oral and Maxillofacial Surgery, Kagoshima City Hospital, Kagoshima, Japan., Natsume N; Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Aichi, Japan., Umeda M; Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Aichi, Japan.
Corporate Authors: Research Committee of the Japanese Society of Oral Care
Source: PloS one [PLoS One] 2026 Apr 08; Vol. 21 (4), pp. e0345991. Date of Electronic Publication: 2026 Apr 08 (Print Publication: 2026).
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0345991