Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.

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Title: Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.
Authors: Zhang X; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA; Eli Lilly and Company, Indianapolis, USA., Ye Z; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Cui S; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Shmushkovich T; Eli Lilly and Company, Indianapolis, USA., Tani H; Eli Lilly and Company, Indianapolis, USA., Chen Y; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Coe M; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Arkhangelskiy A; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Arral ML; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Savvidou MG; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Power L; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Liu L; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Zhao Y; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Howell J; Eli Lilly and Company, Indianapolis, USA., Liu X; Eli Lilly and Company, Indianapolis, USA., Marcet EC; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Ho SM; Eli Lilly and Company, Indianapolis, USA., Que Z; Eli Lilly and Company, Indianapolis, USA., Leung G; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Mullis AS; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Xu Q; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA. Electronic address: qiaobing.xu@tufts.edu., Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA. Electronic address: david.kaplan@tufts.edu.
Source: Biomaterials [Biomaterials] 2026 Oct; Vol. 333, pp. 124202. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-5905
DOI:10.1016/j.biomaterials.2026.124202